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The Connelly lab is interested in understanding the chemical modification, methylation, and its affect on DNA and DNA structure. We are particularly interested in this “DNA mark” as it relates to complex disease. DNA methylation is responsible for regulating gene expression, we believe that individuals vary in the amount of methylated DNA within their genome and that this leads to slight changes in gene expression between individuals. These changes may account for some of the differences we see in complex disease risk, onset, and complications. These DNA marks may be both heritable and environmentally influenced.
Image from, Oxford Journal
